Table 2.

Dosing and monitoring schedule

	Day 0					Day 1			Day 2 to 9	Day 10
Time (T)	Initial visit	T0*	T1a	T1 + 3 hours (±0.5 hours)	T1 + 8 hours (±1 hours)	T1 + 22 hours (±2 hours)	T2b	T2 + 4 hours (±2 hours)		Final visit (±2 days)
Description	V1			V2	V3	V4		V5		VF
Location	Clinic	Clinic	Clinic	Clinic	Clinic	Clinic	Clinic	Clinic	Home	Clinic
Activity		Administer s.c. injection Anaesthesia induction	Extubation				First oral dose		Once-daily oral dosesc

s.c.: subcutaneous; V: visit; VF: final visit.

^*The s.c. first drug administration was close to the time of anaesthetic induction (T0).

^aTime of extubation if the cat was intubated during anaesthesia or return of palpebral reflex if not intubated (T1).

^bThe first tablet was administered by the dispenser approximately 24 hours after the s.c. administration (T2).

^cTablets were administered from Day 2 to the day preceding the VF by the owner. The total duration of oral dosing was 9 days (range, 7–11 days).