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. 2015 Mar 31;9:46. doi: 10.3389/fnsys.2015.00046

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Copyright © 2015 Smith, Pati, Wang, de Kloet, Frazier and Krause.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Angiotensin receptor blockade attenuates restraint-induced c-fos expression in the subfornical organ (SFO). (A) Sixty-minute restraint elicits elevations in adrenocorticotropic hormone (ACTH), corticosterone (CORT), and plasma renin activity (PRA) with similar peaks at 15 min (n = 8 per group and time point). (B) Restraint significantly increases c-fos mRNA in the SFO asterisk (*), different than 0 min; pound sign (#), different than 120 min; *,#p < 0.05, n = 8 per group). (C) Restraint-induced c-fos mRNA expression in the SFO is attenuated by systemic pretreatment with the AT1 receptor antagonist losartan (*p < 0.05, n = 6 per group). Reprinted with permission from Krause et al. (2011b).