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. 2015 Mar 31;6:115. doi: 10.3389/fgene.2015.00115

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Copyright © 2015 Botella, Albiñana, Ojeda-Fernandez, Recio-Poveda and Bernabéu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Circulating protein biomarkers in HHT. (A) The levels of TGF-β1 secreted (over 7 h) by 15 different HUVEC with HHT1 were significantly different (*p < 0.05) from the control HUVEC (C) tested in the same experiment. (B) VEGF plasma concentration levels in 25 healthy controls and 18 HHT patients. The mean values and the standard deviation are given for each group (*p < 0.001). (C) Plasma levels of Ang-2 and (D) plasma levels of sEng in healthy donors (n = 38), patients with HHT1 (n = 32) and patients with HHT2 (n = 30). Significant differences between groups (**p < 0.01) are shown. Adapted from Letarte et al. (2005) (A), Sadick et al. (2005) (B), and Ojeda-Fernandez et al. (2010) (C,D).