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PI3-kinase and p35/Cdk5 pathways regulate ErbB4-mediated chemotaxis of cortical cells in vitro. (A) Scansite software, predicting PI3-kinase-binding and Cdk5-targeted phosphorylation sites of ErbB4. (B) Chemotactic response of Cx-derived cells, untreated or treated simultaneously with DMSO, Roscovitine (10 μM) or LY294002 (10 μM) for 30 min prior to assay, to NRG1β. (C) Chemotactic response of Cx-derived cells, wt or p35-KO, to NRG1β. *P ≤ 0.05, ***P ≤ 0.005, t-test.
