TABLE 1.

Univariable (log rank) and multivariable (Cox regression) analysis of clinical, pathological, and molecular variables

Variable	Univariable analysisa			Multivariable analysisb
	n	7-year DSS (%)	P-Value	Hazard ratio	95% CI	P-Value
Men	111	54	0.07
Women	262	61
Age ≤ 67 years	251	55	0.17
Age ≥ 67 years	283	61
Proximal to splenic flexure	198	60	0.87
Distal to splenic flexure	336	57
Tumor grade I	25	60	0.75
Tumor grade II	432	58
Tumor grade III	77	58
Mucinous cell type	76	59	0.78
Nonmucinous cell type	458	57
PNI present	41	48	0.0004	1.38	0.71–2.70	0.34
PNI absent	349	63
LVI present	109	46	0.0004	1.07	0.64–1.77	0.80
LVI absent	406	60
Stage IV versus I	147	8	<0.0001	25.6	9.1–71.4	<0.0001
Stage III versus I	124	67		9.4	5.2–17.2
Stage II versus I	171	80		6.2	3.7–10.5
Stage I	92	92
Chemotherapy	178	44	<0.0001	1.04	0.55–1.98	0.91
No chemotherapy	212	78
Preop CEA > 5.0 ng/ml	179	42	0.001	1.22	0.73–2.04	0.46
Preop CEA normal	252	80
MSI	58	92	<0.0001	0.18	0.06–0.60	0.005
MSS	420	53
KRAS mutant	190	46	0.0002	1.75	1.15–2.67	0.009
KRAS wild type	342	64

LVI lymphovascular invasion, PNI perineural invasion, CEA carcinoembryonic antigen, Preop preoperative

^aKaplan–Meier with P-values calculated by log-rank test

^bCox regression (backwards stepwise)