TABLE 3.

Motor, cognitive and neuropsychiatric/behavioural symptoms in progressive supranuclear palsy, corticobasal degeneration, and multiple system atrophy

	Motor symptoms	Cognitive deficits	Neuropsychiatric/behavioral symptoms
Progressive supranuclear palsy	Rigidity (axial), bradykinesia, occasional tremor, postural instability, ophthalmoparesis, swallowing difficulties (late stage)	Executive dysfunction155,161,162: Fluency both semantic and phonemic) – often more severe than MSA/PD154,162 Initiation & perseveration, slowed cognitive speed and impaired flexibility/set shifting. Memory (although recognition relatively preserved)	Apathy, depression, sleep problems, irritability, disinhibition, bulbar affect, eating problems
Corticobasal degeneration	Unilateral parkinsonism including rigidity, bradykinesia, and occasional tremor. Postural instability Cortical “movement disorders”: apraxia myoclonus alien-limb phenomena cortical sensory loss	Executive dysfunction: set shifting,163 reduced word fluency164 Constructional apraxia are also usual findings165 Episodic memory function deficits Speech difficulties166	Depression, apathy, agitation, irritability. Occasionally Kluver-Bucy syndrome.
Multiple system atrophy	Rigidity, bradykinesia, occasional tremor, postural instability	Executive dysfunction155,162: language deficits (fluency), initiation & perseveration, cognitive speed/flexibility	Depression and anxiety are common (perhaps less so than in PSP).167 Sleep disorders common as well (perhaps more than in PD for a similar disease duration)168

Abbrevations: MSA: multiple system atrophy; PSP: progressive supranuclear palsy.