Fig. 5.

Both single treatment with WR-2721 or PGN and combination treatment augmented intestinal Lgr5 expression and activated NF-κB following irradiation. (A) The percentage of Lgr5⁺ cells in the ilea of mice treated with WR-2721 and PGN was higher than that in the ilea of mice irradiated with 10 Gy, but lower than the percentage in the ilea of normal mice (*P < 0.05). (B) The NF-κB p65 subunit is located in the cytoplasm 1.25 days post 10 Gy irradiation. Both WR-2721 and PGN treatment may activate NF-κB and induce it to move into the nuclei of such cells as enterocytes and smooth muscle cells. (C) Western blot data of phospho-IκBα in the ileum 1.25 days post 10 Gy irradiation.