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. 2014 Dec 30;24(8):2163–2174. doi: 10.1093/hmg/ddu736

Figure 3.

Figure 3.

Immunofluorescence micrographs of sections of spinal cord stained with anti-NFL-N antibody showing inclusions in NeflN98S/+ mice. (A) Section of anterior horn of 18-month-old Nefl+/+ (WT) mouse. (B) Section of anterior horn of 18-month-old NeflN98S/+ (N98S) mouse. (C) Section of posterior horn of 18-month-old Nefl+/+ (WT) mouse. (D) Section of posterior horn of 18-month-old mutant NeflN98S/+ (N98S) mouse. WM of Nefl+/+ mice shows axonal labeling, whereas there is relatively little labeling in the cell bodies of the GM in both the anterior and posterior horns. In contrast, there was relatively little labeling in the WM of NeflN98S/+ mice, except for the inclusions (arrow), which are likely due to axonal swellings. Inclusions are also observed in the GM in both the anterior and posterior sections (arrows). Bars = 50 μm.