Table 5.
Percent of embryos exhibiting lesions with TAME exposure.
| Control | 0.625mM TAME |
1.25mM TAME |
2.5mM TAME |
5.0mM TAME |
10.0mM TAME |
|
|---|---|---|---|---|---|---|
| All Lesions | 7.5 (± 7.5) | 20 (± 15) | 45 (± 15)* | 70 (± 5)* | 92.5 (± 2.5)* | 90 (± 10)* |
| Death (by 120hpf) | 2.5 (± 2.5) | 0 (± 0) | 2.5 (± 2.5) | 2.5 (± 2.5) | 7.5 (± 7.5) | 45 (± 35)* |
| Hatch (at 120hpf) | 92.5 (± 2.5) | 87.5 (± 2.5) | 85 (± 10) | 82.5 (± 7.5) | 67.5 (± 2.5)* | 0 (± 0)* |
| 3dph Survival | 97.5 (± 7.5) | 87.5 (± 7.5) | 87.5 (± 7.5) | 92.5 (± 2.5) | 67.5 (± 2.5) | 0 (± 0)* |
| Reduced Circulating RBCs | 0 (± 0) | 2.5 (± 2.5) | 10 (± 0) | 25 (± 10) | 65 (± 15)* | 90 (± 10)* |
| Pericardial Edema | 0 (± 0) | 2.5 (± 2.5) | 12.5 (± 2.5) | 12.5 (± 2.5) | 40 (± 7.5)* | 72.5 (± 27.5)* |
| Pooled Blood in CCV§ | 2.5 (± 2.5) | 7.5 (± 2.5) | 17.5 (± 2.5) | 27.5 (± 2.5) | 72.5 (± 2.5)* | 27.5 (± 22.5) |
| Cranial Hemorrhage§ | 2.5 (± 2.5) | 10 (± 5) | 25 (± 10) | 40 (± 10)* | 32.5 (± 5)* | 7.5 (± 7.5) |
| Abnormal ISVs§ | 0 (± 0) | 12.5 (± 2.5) | 20 (± 5) | 32.5 (± 12.5)* | 65 (± 5)* | 15 (± 15) |
| Yolk Edema | 0 (± 0) | 0 (± 0) | 5 (± 0) | 10 (± 0) | 50 (± 0)* | 90 (± 10)* |
| Yolk Dysmorphogenesis | 0 (± 0) | 0 (± 0) | 0 (± 0) | 0 (± 0) | 92.5 (± 7.5)* | 62.5 (± 37.5)* |
Values in the table are percentages (± range) based on the average number of embryos in each category from replicate studies. (N=20)
*
Significantly different from control (P ≤ 0.05). § MTBE-induced vascular lesion