Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Apr 1;16(1):69. doi: 10.1186/s13059-015-0605-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Uribe-Lewis et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Reduced 5hmC in tumours without global changes in TET s transcripts. (a) Global content of 5hmC and 5mC in normal (N), adenoma (Ad) and adenocarcinoma (T) DNA by mass spectrometry (P values were obtained by a Wilcox test). (b) Representative images from a colon cancer tissue microarray immunofluorescence. Arrows indicate the epithelium, arrowheads the stroma. (c) Absolute levels of TETs (standard curve method) in selected cases from our colon cancer cohort. Orange vertical bands represent the median. Negative values indicate TETs transcripts are less abundant than B2M transcripts. There was no significant change in levels across tissues but considerable variation within tissues.