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. 2015 Mar 13;35(5):1199–1212. doi: 10.3892/ijmm.2015.2136

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Copyright © 2015, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Activated protein C (APC) reduces pro-inflammatory cytokine production in fetal rat brains on embryonic day (E)19 after maternal exposure to lipopolysaccharide (LPS). (A–C) mRNA expression of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) in the fetal rat brains on E19. (D–F) Protein levels of TNF-α, IL-1β and IL-6 in the fetal rat brains on E19. Data are presented as the means ± SD (n=4–6 per group). ^*P<0.05, ^**P<0.01, ^†P<0.001 as compared with LPS group.