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. Author manuscript; available in PMC: 2015 Mar 31.
Published in final edited form as: Virology. 2008 Sep 17;381(1):46–54. doi: 10.1016/j.virol.2008.08.025

Figure 5. Aptamer binding site.

Figure 5

Location of gp120 residues important for B40 aptamer binding mapped onto a V3-containing gp120 core structure derived from the primary isolate JR-FL (Huang et al., 2005). Top panel: Surface rendering of gp120JR-FL core+V3 depicting residues identified by mutagenesis as important for CCR5 binding (cyan) (Cormier et al., 2001; Rizzuto and Sodroski 2000; Rizzuto et al., 1998) and residues identified in this study by alanine mutagenesis that significantly reduce aptamer binding (orange). The locations of the V1/V2 stem, V3 and V4 are denoted for orientation purposes. Bottom panel: Ribbon model of gp120JR-FL+V3 depicting a close-up of the residues important for B40 binding (orange; space-filling models).

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