Table 2. Genotype odds ratios from the original studies reporting an association.
Ratios from the PDK4 locus (Meurs et al., 2012) and Chromosome 5 SNP (Mausberg et al., 2011). The PDK4 χ2 test results indicate that the WtWt genotype significantly associated with non-DCM and the WtDel genotype significantly associated with DCM at the 0.01 significance level, the DelDel genotype odds ratio whilst different from the null result of 1, is not significantly so. For the chromosome 5 SNP all individuals that are CC in the original study developed DCM, thus and odds ratio and confidence interval cannot be calculated, but χ2 tests can be performed on the data. TT is significantly associated with non-DCM and the TC and CC genotypes are significantly associated with DCM at the 0.01 significance level.
| Genotype | Odds ratio | 95% CI |
|---|---|---|
| PDK4 WtWt | 0.14 | 0.07, 0.32 |
| PDK4 WtDel | 5.21 | 2.70, 12.09 |
| PDK4 DelDel | 1.14 | 0.41, 3.18 |
| Chr5 TT | 0.11 | 0.05, 0.24 |
| Chr5 TC | 6.23 | 2.78, 14.00 |
| Chr5 CC | NA | NA |