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. Author manuscript; available in PMC: 2015 Jun 4.
Published in final edited form as: Nature. 2014 Dec 4;516(7529):121–125. doi: 10.1038/nature13980

Figure 1. Piezo2 is localized at the nerve terminals of sensory neurons that innervate the skin.

Figure 1

a and b, representative images of immunostaining of GFP, Nefh and DAPI (blue) in the hair follicle of the Piezo2-GFP dorsal skin. GFP staining indicates localization of the Piezo2-GFP fusion protein and Nefh marks myelinated neurons. c, representative image of immunostaining of GFP, Krt8, a specific marker of Merkel cells, and DAPI (blue) in the Piezo2-GFP glabrous skin. d, representative images of immunostaining of GFP and S100, a marker of Schwann cells, in glabrous skin. Arrows mark lanceolate endings (a) and arrowheads mark circumferential fibers (b). Dashed lines demarcate epidermal-dermal junction (c and d). HS, hair shaft; Epi, epidermis; Der, dermis. Scale bars (a-d) 20μm.