Extended Data Table 2.
Properties of single fibers recorded from Piezo2WT and Piezo2CKO using the saphenous nerve ex vivo skin nerve preparation.
| a | |||
|---|---|---|---|
| Subclass | Piezo2WT | Piezo2CKO | |
| Aβ-fibers | SAM I | 22 | 7 |
| SAM II | 9 | 3 | |
| RAM | 20 | 7 | |
| Aδ-fibers | D-Hair | 10 | 4 |
| A-M | 17 | 21 | |
| C-fibers | C-LT | - | - |
| C-M | 5 | 2 | |
| C-MH | 15 | 8 | |
| C-MHC | 4 | 3 | |
| b | |||
|---|---|---|---|
| Piezo2WT | Piezo2CKO | ||
| Mechanically Sensitive | 84 | 58 | |
| Mechanically Insensitive | 4 | 13 | |
a, mechanical search protocol and b, electrical search protocol. Definitions as follows C-LT, C-fiber with low threshold mechanosensitivity; C-M, C-mechano-nociceptor only responding to mechanical stimulation and not noxious cold or heat, C-MH, C-mechano heat, responding both to noxious heat and mechanical stimuli; C-MHC, C-mechano heat/cold fiber responding to noxious mechanical heat and cold. Note that small discrepancies between the numbers of fibers listed here and those tested with the full series of mechanical stimuli are due to technical issues preventing full characterization of the unit.