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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Int J Radiat Biol. 2014 Jun 25;90(9):753–761. doi: 10.3109/09553002.2014.922722

FIGURE 8.

FIGURE 8

Irradiation to the skin decreases newly synthesized collagen in the lungs. Acid and pepsin soluble collagen in the lung was measured using Sircol, at 210 days after irradiation in 2 groups of rats: (i) pooled 13 Gy whole thorax irradiation (WTI) from two separate experiments (open bar) (ii) 13 Gy WTI+30 Gy to the skin (grey bar). Number of rats in each group are indicated in the bar. * indicates p<0.05 between lung collagen in the 2 groups of rats. Collagen has been previously reported to be increased at 210 days after 13 Gy as compared to unirradiated age-matched control rats (Kma et al. 2012). Unirradiated rats using the same model and collagen assay at 210 days had 14.6±0.2 μg collagen/mg wet weight of lung (n=5) (Kma et al. 2012).