Table 3.
Association of CA-125 levels during treatment with progress-free survival (PFS) and overall survival (OS).
| PFS |
OS |
|||||
|---|---|---|---|---|---|---|
| HR | 95% C.I. | P value | HR | 95% C.I. | P value | |
| Baseline CA125 | ||||||
| Log2(CA125) | 1.10 | 1.02–1.18 | 0.009 | 1.09 | 1.01–1.17 | 0.032 |
| ≥35 versus < 35 U/ml | 0.99 | 0.65–1.52 | 0.961 | 1.16 | 0.71–1.90 | 0.565 |
| Pre-2nd cycle | ||||||
| Log2(CA125) | 1.24 | 1.15–1.34 | <0.001 | 1.26 | 1.16–1.37 | <0.001 |
| ≥35 versus < 35 U/ml | 1.98 | 1.47–2.66 | <0.001 | 2.88 | 2.01–4.16 | <0.001 |
| Pre-4th cycle | ||||||
| Log2(CA125) | 1.39 | 1.21–1.59 | <0.001 | 1.46 | 1.26–1.68 | <0.001 |
| ≥35 versus < 35 U/ml | 1.80 | 1.27–2.56 | 0.001 | 1.94 | 1.31–2.85 | <0.001 |
| Pre-6th cycle | ||||||
| Log2(CA125) | 1.35 | 1.13–1.61 | 0.001 | 1.61 | 1.32–1.96 | <0.001 |
| ≥35 versus < 35 U/ml | 2.45 | 1.52–3.95 | <0.003 | 2.78 | 1.66–4.65 | <0.001 |
Hazard ratio (HR) estimated from Cox model adjusted for tumor residual, histology and type of chemotherapy.