Table 2. Antiplasmodial Activities for 1 and 2 Compared to Chloroquine against Chloroquine-Sensitive (D6) and -Resistant (Dd2 and 7G8) Strains of Plasmodium falciparum.
IC50 (nM) against plasmodial strain |
|||
---|---|---|---|
test compound | D6 | Dd2 | 7G8 |
companeramide A (1) | 570 | 1000 | 1100 |
companeramide B (2) | 220 | 230 | 700 |
chloroquine | 5 | 80 | 71 |