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. 2015 Apr;145(4):303–314. doi: 10.1085/jgp.201411292

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© 2015 Ohrtman et al.

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Figure 5. — Ca²⁺ currents produced by expression in dysgenic myotubes of rabbit YFP-Ca_V1.1₁₈₆₀ or of YFP-Ca_V1.1₁₆₆₆ lacking the distal C terminus. In vivo, proteolytic cleavage has been reported to sever after residue 1,664 (Hulme et al., 2005). (A) Representative currents from dysgenic myotubes expressing cDNA encoding either YFP-Ca_V1.1₁₈₆₀ (top) or YFP-Ca_V1.1₁₆₆₆ (bottom), elicited by 200-ms depolarization to the indicated potentials. (B) Average peak current versus voltage relationships for YFP-Ca_V1.1₁₈₆₀ (●) and YFP-Ca_V1.1₁₆₆₆ (◆), with the number of experiments given in parentheses. The smooth curves represent plots of Eq. 1, with the average values determined by best fits to the data from individual cells. Error bars indicate ± SEM.