Table 1.
Characteristics of recurrence cases and controls
| Cases | Controls | P-value | |
|---|---|---|---|
| Age at surgery, years | |||
| Mean (s.d.) | 58.7 (6.1) | 58.9 (5.8) | Matched |
| Race, % | |||
| Caucasian | 85 | 88 | Matched |
| Pre-operative serum PSA, ng/ml | |||
| Mean (s.d.) | 12.3 (10.4) | 11.2 (8.5) | 0.21 |
| Median (IQR) | 9.1 (8.6) | 8.7 (7.2) | 0.22 |
| Follow-up time, years | |||
| Mean (s.d.) | 2.5 (1.9) | 5.9 (2.4) | <0.001 |
| Median (IQR) | 2 (2) | 6 (4) | <0.001 |
| Gleason score, % | Matched | ||
| ≤6 | 15 | 15 | |
| 7 | 61 | 63 | |
| ≥8 | 24 | 22 | |
| Pathological stage, % | Matched | ||
| T2 | 13 | 13 | |
| T3a | 51 | 51 | |
| T3b or N1 | 36 | 36 | |
| PTEN mean H-Score | |||
| Mean (s.d.) | 105.5 (93.6) | 112.4 (85.3) | 0.19 |
| Median (IQR) | 100 (175.8) | 102.5 (166) | 0.08 |
| PTEN expression, % | |||
| Mean H-score = 0 | 16 | 11 | 0.05 |
| All TMA spots | 40 | 31 | 0.02 |
| markedly decreaseda |
Abbreviations: IQR, interquartile range; TMA, tissue microarray.
a
Limited to matched pairs with three to six TMA spots evaluated per patient (N = 714).