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. Author manuscript; available in PMC: 2015 Mar 31.
Published in final edited form as: J Invest Dermatol. 2013 Apr 18;133(10):2444–2452. doi: 10.1038/jid.2013.187

Table 1.

PCR-validated gene targets of p300 HAT.The numbers indicate the relative expression level fold change in cells treated with C646 for 24 h over the DMSO control. Descriptions of gene functions are taken from PubMed gene search. “-” indicates that no broad cellular function has been associated with a particular gene.

Gene Fold Change Known Function(s)
Repressed
family with sequence similarity 111, member B FAM111B -42.5 -
histone cluster 1, H2bb HIST1H2BB -29.1 chromatin assembly
ubiquitin-like with PHD and ring finger domains 1 UHRF1 -14.5 G1/S transition, p53-dependent DNA damage checkpoint
cyclin E2 CCNE2 -12.7 G1/S transition
DEP domain containing 1 DEPDC1 -12.4 Inhibition of apoptosis
X-ray repair complementing defective repair in Chinese hamster cells 2 XRCC2 -11.3 homologous recombination
cyclin A2 CCNA2 -7.2 G1/S and G2/M transition
RAD51 homolog RAD51 -5.6 homologous recombination
Bloom syndrome, RecQ helicase-like BLM -5.3 3′-5′ helicase activity, suppression of inappropriate recombination
breast cancer 2, early onset BRCA2 -4.2 homologous recombination
replication protein A2 RPA2 -2.6 homologous recombination

Overexpressed
protease, serine, 35 PRSS35 5.7 -
tripartite motif containing 38 TRIM38 4.3 -
microRNA 34a MIR34A 2.6 -
tissue inhibitor of metalloproteinase 3 TIMP3 2.4 irreversible inactivation of metalloproteinases
tumor protein p53 TP53 1.2 response to diverse cellular stresses, promotion of cell cycle arrest, apoptosis, senescence and DNA repair
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