Fig. 7. Gene expression effects associated with L1 insertions.

(A) For lung and colon cancers, each bar represents the difference between the log₁₀ (FPKM) for the target gene in the relevant sample compared to the average log₁₀(FPKM) for other samples of that tumor type. FPKM, fragments per kilobase of transcript per million mapped reads. Genes with FPKM > 1 average expression have darker bars. (B) Scatter plot showing the data in (A).The y axis shows the log₁₀(FPKM) for the target gene in the relevant sample, and the x axis shows the average log₁₀(FPKM) for that gene for other samples of that tumor type. In expressed genes [mean log₁₀(FPKM) > 0], the expression level in the affected sample is very close to the overall expression level of the gene in the corresponding tissue. Most large expression level differences occur at unex-pressed genes [mean log₁₀(FPKM) < 0].