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. Author manuscript; available in PMC: 2016 Mar 27.
Published in final edited form as: Circ Res. 2015 Mar 27;116(7):1101–1103. doi: 10.1161/CIRCRESAHA.115.306052

Figure. Current (A) and proposed (B) models for how different HDL species promote cholesterol efflux from macrophages.

Figure

Figure

Both ABCA1 and ABCG1 are transmembrane proteins but they promote sterol efflux by different mechanisms. ABCA1 exports cholesterol from the plasma membrane to cholesterol acceptors, while ABCG1 is an intracellular sterol transporter that enriches the plasma membrane with cholesterol. See the text for additional details. FC, cholesterol; CE, cholesteryl ester; LCAT, lecithin-cholesterol acyltransferase.