Table 2.

Area under the ROC curve analysis for the significant clinical and imaging variables

	AUROC	Sensitivity (%)	Specificity (%)	PPV (%)
Clinical variables
Action fluency	0.76	83	60	38
VOSP Cube Analysis	0.77	67	80	50
MRI volumes
Right lateral temporal	0.92	83	100	100
Right lateral parietal	0.88	83	90	71
Right lateral frontal	0.88	100	65	46
FDG uptake values
Left hippocampus	0.83	83	95	83
Left temporal pole	0.86	83	95	83
Left medial frontal	0.80	100	50	38
Right lateral temporal	0.90	67	100	100
Right lateral parietal	0.82	67	90	67
Right lateral frontal	0.78	67	95	80
MRI asymmetry scores
Hippocampus	0.84	83	100	100
Lateral temporal	0.86	83	90	71
Temporal pole	0.88	83	90	71
FDG asymmetry scores
Hippocampus	0.84	83	100	100
Lateral temporal	0.82	83	90	71
Temporal pole	0.89	83	95	83
Medial frontal	0.84	67	100	100
DTI asymmetry scores
IFO FA	0.79	83	79	56
IFO MD	0.78	67	100	100

IFO = inferior fronto-occipital fasciculus; FA= fractional anisotropy; MD = mean diffusivity Values shown to optimize accuracy to diagnose PiB-negative patients (optimum defined as the greatest sens – (1-spec)).