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. Author manuscript; available in PMC: 2016 Mar 2.
Published in final edited form as: Curr Protoc Mouse Biol. 2015 Mar 2;5(1):35–49. doi: 10.1002/9780470942390.mo140161

Figure 4. Marrow ablation procedure.

Figure 4

A: Three different needle sizes required for progressive ablation of the tibia. B: The knee is maximally flexed. C: A 2-3 mm longitudinal incision is made centered over the knee. D: An incision is made medial to the patella, which extends into the quadriceps muscle and along the patella tendon to release the tissue. The patella is subluxated laterally. E, F, G: The proximal tibia is instrumented and progressively larger needles are used to ablate the medullary canal.