Table 2.
Rates of prenatal medication use, eczema and sensitization (sIgE ≥0.35 IU/ml) at age 2 years in the WHEALS birth cohort.
| All Children N=596 | Children born Vaginally N=376 | Children born via C-section N=220 | p value‡ | |
|---|---|---|---|---|
| Administered or prescribed any antibiotic* in pregnancy | 341 (57.2%) | 223 (59.3%) | 118 (53.6%) | 0.18 |
| Administered or prescribed any antibiotic* in pregnancy that was: | ||||
| - Systemic | 328 (55.0%) | 213 (56.7%) | 115 (52.3%) | 0.30 |
| - Topical | 15 (2.5%) | 11 (2.9%) | 4 (1.8%) | 0.40 |
| - Vaginal insert | 25 (4.2%) | 15 (4.0%) | 10 (4.5%) | 0.74 |
| Administered or prescribed any antifungal* in pregnancy | 116 (19.5%) | 67 (17.8%) | 49 (22.3%) | 0.19 |
| Administered or prescribed any antifungal* in pregnancy that was: | ||||
| - Systemic | 55 (9.2%) | 32 (8.5%) | 23 (10.4%) | 0.43 |
| - Topical | 4 (0.7%) | 3 (0.8%) | 1 (0.4%) | 0.62 |
| - Vaginal insert | 71 (11.9%) | 39 (10.4%) | 32 (14.5%) | 0.13 |
| Administered either an antibiotic or antifungal medication in pregnancy | 377 (63.3%) | 243 (64.6%) | 134 (60.9%) | 0.36 |
| Eczema at age 2 years N=59 missing eczema data |
118 (22.0%) | 66 (19.3%) | 52 (26.7%) | 0.047 |
| Sensitized to at least 1 allergen at age 2 years N=146 missing sensitization data |
232 (51.6%) | 138 (48.2%) | 94 (57.3%) | 0.064 |
| Mom was Group B Strep positive† | 222 (37.2%) | 132 (35.1%) | 90 (40.9%) | 0.16 |
| Mom was Group B Strep positive N=63 missing data |
159 (29.8%) | 104 (29.9%) | 55 (29.7%) | 0.97 |
| Geometric mean (95% CI) of total IgE at 2 years of age | 22.0 (19.4, 25.0) | 21.7 (18.4, 25.6) | 22.6 (18.6, 27.5) | 0.71 |
*
By medication type based on therapeutic goal
†
Assumes those with missing status are treated the same as those who are positive.
‡
p-value is for the comparison of those born vaginally versus those born by c-section.