Table 3. PBPK Models of Infant Internal Dose of BPA.

Authors and publication year	Published Sources of Model Inputs*	Age groups modeled	Free BPA Steady State Serum Concentration (μg/L)	Free BPA Peak Serum Concentration (μg/L)	Bioavailability*
Mielke and Gundert-Remy. 200942	Intake Rates: EFSA 200643; EU 200844 TK Parameters: Kuester and Sipes 200745 TK Scaling factors: Edginton and Ritter 200652	Newborn 3 months 6 months 6-12 months, 1.5 years 1.5-4.5 years Adult	0.096 (pc bottle) 0.0008 (breast), 0.020 (non-pc bottle) 0.096 (pc bottle) 0.030 0.0085 0.010 0.012 o.oo4	0.34 (pc bottle) 0.0033 (breast), 0.071 (non-pc bottle) 0.34 (pc bottle) 0.17 0.049 0.059 0.069 0.023	Not reported
Edginton and Ritter 200946	Intake Rates: EFSA 200643; Ye et al. 200847 TK Parameters: Volket et al. 200217 TK Scaling factors: Edginton and Ritter 200652	Newborn 3 months 6 months 1.5 years adult	Presented in graph. Exact values not reported.	Not modeled.	88% 48% 32% 23% 18%

^*TK Parameters=toxicokinetic parameters for adults, TK scaling factors=fraction of adult enzyme activity based on age of infant or child

^**Fraction absorbed orally compared with IV absorption

EFSA=European Food Safety parameters