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. 2015 Mar 31;10(3):e0121707. doi: 10.1371/journal.pone.0121707

Fig 2. The tumor cells invade the ventricular system.

Fig 2

A- Septo-Striatal section, phase contrast (tissue slides, 1X); B- The same Septo-Striatal section: Ki-67 (red) overlay with GFP (green) and DAPI (blue) (LC25-R—8 weeks post-injection) (tissue slides, 1X); C- (LC26-R—12 weeks post-injection), D- (LC35TR-R—12 weeks post-injection), and E- (LCAS-R—12 weeks post-injection)—tumor growing within the parenchyma of the subventricular zone protruding to the ventricle (HE- 5X, 20X and 10X respectively); F- tumor growing within the parenchyma and invading lateral ventricle (LC26-R—12 weeks post-injection) (HE- 5X); G- tumor growing within the parenchyma, Ki-67 staining (LC26-R—12 weeks post-injection) (HE- 20X); H- tumor growing within the ventricular system including forth ventricle and subarachnoid space permeating the cerebellum (LC26-R—12 weeks post-injection) (HE- 5X); I- Tumor growing inside the parenchyma and protruding into the ventricular space. (CM14R - 8 weeks post-injection) (HE- 10X, inserts- 4X digital); J- and K- poorly differentiated neuroblastic tumor with rosette formation (LC26-R—12 weeks post-injection) (HE- 40X), rosettes—orange arrows; L- and N- frequent atypical mitoses—yellow arrows and inserts (LC26-R—12 weeks post-injection) (HE- 40X, inserts- 6X digital); M- tumor perivascular invasion (LCAS-R—12 weeks post-injection) (HE— 40X); N- and O—prominent angiogenesis—red arrows and insert (LC26-R—12 weeks post-injection) (HE- 40X, insert- 5X digital); P- geographic necrosis with pseudo-palisades (LCAS-R—12 weeks post-injection) (HE— 10X).TU—tumor; P—parenchyma; V—ventricle; CP—choroid plexus; CBL—cerebellum; N—necrosis.