Fig 4. Polymorphic population of RG cells.
A- and B- wild type RG cell line shows polymorphic population of cells with neuroectodermal differentiation (HE— 40X, inserts digital magnification 4X and 10X); C- and D- OTX2 expressed in early stages of differentiation among wild type RG cells (C— 40X, inserts digital magnification 4X) and in the majority of tumor cells (LCAS-R—12 weeks post-injection) (D— 40X, inserts digital magnification 4X); E- and F- BLBP expressed in neuronal differentiated cells within wild type RG cells (E— 40X, inserts digital magnification 4X) with loss of expression in most of the tumor cells (LCAS-R—12 weeks post-injection) (F— 40X, inserts digital magnification 4X).