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. 2015 Mar 31;10(3):e0118875. doi: 10.1371/journal.pone.0118875

Fig 2. RA treatment suppresses IFN-γ during DSS in WT mice but enhances their secretion in TLR2KO mice.

Fig 2

(A) Mucosal scrapings from mice receiving the DSS and water were harvested on day 10 and analyzed by ELISA for cytokine levels. (B) Quantitative RT-PCR for transcription factors associated with T helper subsets were also performed on colonic lamina propria samples taken at day 14. Data shown are the fold increase of Vehicle- and RA-treated mice compared to naive controls. Data are the mean ± SEM of 5–8 mice per group pooled from two independent experiments. (C) Expression of Foxp3 and IL-10 in colonic LP CD4+ T cells (n = 3 per group), one representative facs plot is shown. *, p < 0.05, **, p < 0.01 using Student’s t-test.