Table 2. IC50 and CC50 of selected hits.
Compound | IC50 (μM) | CC50(μM) | SI = CC50/IC50 |
---|---|---|---|
Combrestatin 1 | 0,12 ± 0,0013 | 4,33 ± 0,49 | 33,7 |
Combrestatin 2 | 0,071 ± 0,0033 | 2,65 ± 0,21 | 37,3 |
Carbolin 1 | 1,44 ± 0.05 | >200 | 138 |
Carbolin 2 | 5,24 ± 0.26 | >200 | 38 |
Indenoisoquinoline | 0,0113 ± 0,0019 | 0,33 ± 0,050 | 30 |
SI: Ratio of CC50 to IC50. Data are displayed as mean ± SD of three independent experiments.