Fig. 5.
PTPα is required for collagen gel contraction. A: 2 × 105 PTPαwt and PTPα−/− cells were embedded in polymerized collagen gel, deposited as 1-ml aliquots over 24-well tissue culture dishes, and covered with normal medium. Gels were detached after 1 day. B: 2.29 × 104 PTPαwt and PTPα−/− cells were embedded in polymerized collagen gel, deposited as 200-μl aliquots over nontissue culture dishes, and covered with tissue culture medium. Diameter of each gel was measured on 4 consecutive days. Values are means ± SD of 3–5 collagen gels per cell line in 3 independent experiments.