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Hypothetical model showing the regulation of KIM-1-mediated efferocytosis by receptor shedding. A: spontaneous KIM-1 shedding does not affect the efficiency of KIM-1-dependent efferocytosis. B: competitive inhibition of efferocytosis by decoy (soluble KIM-1) receptors resulting from excess KIM-1 shedding due to exaggerated cellular injury (e.g., H2O2).
