Table 1.
Nx |
|||||
---|---|---|---|---|---|
Sham (n = 10) | 1 wk (n = 7) | 2 wk (n = 13) | 4 wk (n = 11) | 8 wk (n = 9) | |
Body weight, g | 264.1 ± 6.2 | 210.7 ± 6.0† | 231.5 ± 5.9* | 288.4 ± 7.7 | 323.9 ± 12.2† |
Urine volume, ml/day | 6.9 ± 1.0 | 24.8 ± 1.9† | 23.6 ± 1.7† | 26.4 ± 1.8† | 25.3 ± 3.4† |
BUN, mg/dl | 13.5 ± 0.5 | 44.1 ± 6.5 | 57.4 ± 6.5† | 71.0 ± 12.0† | 85.0 ± 15.3† |
PCr, mg/dl | 0.52 ± 0.02 | 1.22 ± 0.18* | 1.23 ± 0.10* | 1.26 ± 0.15* | 1.96 ± 0.32† |
CCr, ml·min−1·kg−1 | 4.42 ± 0.23 | 2.70 ± 0.36† | 2.31 ± 0.22† | 2.46 ± 0.28† | 1.69 ± 0.30† |
Albumin excretion, mg/day | 0.5 ± 0.1 | 3.5 ± 0.3 | 21.5 ± 4.7 | 67.4 ± 4.5* | 128.6 ± 45.2† |
Data represent means ± SE for n rats. Sham, sham-operated rats at 2 wk after surgery; Nx, 5/6 nephrectomized rats; BUN, blood urea nitrogen; PCr, plasma creatinine; CCr, creatinine clearance. Multiple comparison was performed with Dunnett's 2-tailed test after a 1-way ANOVA.
P < 0.05,
P < 0.01, significantly different from Sham.