Table 1.

Biochemical parameters in sham-operated and subtotally nephrectomized rats

		Nx
	Sham (n = 10)	1 wk (n = 7)	2 wk (n = 13)	4 wk (n = 11)	8 wk (n = 9)
Body weight, g	264.1 ± 6.2	210.7 ± 6.0†	231.5 ± 5.9*	288.4 ± 7.7	323.9 ± 12.2†
Urine volume, ml/day	6.9 ± 1.0	24.8 ± 1.9†	23.6 ± 1.7†	26.4 ± 1.8†	25.3 ± 3.4†
BUN, mg/dl	13.5 ± 0.5	44.1 ± 6.5	57.4 ± 6.5†	71.0 ± 12.0†	85.0 ± 15.3†
PCr, mg/dl	0.52 ± 0.02	1.22 ± 0.18*	1.23 ± 0.10*	1.26 ± 0.15*	1.96 ± 0.32†
CCr, ml·min−1·kg−1	4.42 ± 0.23	2.70 ± 0.36†	2.31 ± 0.22†	2.46 ± 0.28†	1.69 ± 0.30†
Albumin excretion, mg/day	0.5 ± 0.1	3.5 ± 0.3	21.5 ± 4.7	67.4 ± 4.5*	128.6 ± 45.2†

Data represent means ± SE for n rats. Sham, sham-operated rats at 2 wk after surgery; Nx, 5/6 nephrectomized rats; BUN, blood urea nitrogen; PCr, plasma creatinine; CCr, creatinine clearance. Multiple comparison was performed with Dunnett's 2-tailed test after a 1-way ANOVA.

^*P < 0.05,

^†P < 0.01, significantly different from Sham.