Table 1. Selected list of coding genes differentially regulated in T cells of patients treated with anti-CTLA4, anti-PD1, combination therapy or sequential therapy.
Selected list of coding genes from the top 30 differentially regulated genes in T cells of patients treated with anti-CTLA4, anti-PD1, combination therapy (concurrent anti-CTLA4 and anti-PD1) or sequential therapy (anti-PD1 following anti-CTLA4 therapy).
| TRANSCRIPT ID |
P VALUE | FOLD CHANGE |
GENESYMBOL | GENEDESCRIPTION |
|---|---|---|---|---|
| Combo Therapy (Anti-CTLA4+ Anti-PD1) | ||||
| 18876628 | 0.01 | 3.17 | MKI67 | antigen identified by monoclonal antibody Ki-67 |
| 18906869 | 0.01 | 2.84 | IFNG | interferon gamma |
| 19224629 | 0.02 | 2.77 | HIST1H3B | histone cluster 1, H3b |
| 18764511 | 0.05 | 2.77 | IL8 | interleukin 8 |
| 18775469 | 0.03 | 2.65 | FGFBP2 | fibroblast growth factor binding protein 2 |
| 18772965 | 0.02 | 2.64 | CCNA2 | cyclin A2 |
| 18949520 | 0.02 | 2.45 | SLC7A5 | solute carrier family 7,member 5 |
| 18966489 | 0.001 | 2.39 | KPNA2 | karyopherin alpha 2 |
| 18923230 | 0.04 | 2.29 | GZMB | granzyme B |
| 18961872 | 0.02 | 2.13 | TOP2A | topoisomerase (DNA)II alpha 170kDa |
| Anti-CTLA4 Therapy | ||||
| 18689122 | 0.021 | 2.33 | FAM46C | family with sequence similarity 46, member C |
| 18876628 | 2.5E-04 | 2.18 | MKI67 | antigen identified by monoclonal antibody Ki-67 |
| 18961872 | 0.002 | 1.59 | TOP2A | topoisomerase(DNA)II alpha 170kDa |
| 18724103 | 0.035 | 1.58 | CTLA4 | cytotoxic T-lymphocyte-associated protein 4 |
| 18797874 | 0.012 | 1.55 | STX11 | syntaxin 11 |
| 19224662 | 0.003 | 1.54 | HIST1H3F | histone cluster1, H3f |
| 18772965 | 0.007 | 1.49 | CCNA2 | cyclin A2 |
| 18906869 | 0.020 | 1.42 | IFNG | interferon gamma |
| 18988349 | 0.001 | 1.42 | TPX2 | TPX2 (microtubule associated) |
| 18724111 | 0.06 | 1.57 | ICOS* | InducibleT-cell co-stimulator |
| Anti-PD1 Therapy | ||||
| 18895449 | 0.028 | 2.67 | KLRF1 | killer cell lectin-like receptor subfamily F, member 1 |
| 18707750 | 0.048 | 2.51 | SH2D1B | SH2 domain containing 1B |
| 18971449 | 0.027 | 2.23 | KIR2DL2 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 |
| 18777270 | 0.021 | 2.07 | GZMA | granzyme A |
| 18988173 | 0.013 | 1.97 | CST7 | cystatin F (leukocystatin) |
| 18718479 | 0.019 | 1.93 | GNLY | granulysin |
| 18707252 | 0.004 | 1.77 | FCRL3 | Fc receptor-like 3 |
| 19011576 | 0.025 | 1.60 | HLA-DMA | major histocompatibility complex, class II, DM alpha |
| 18978382 | 0.039 | 1.53 | NCR1 | natural cytotoxicity triggering receptor 1 |
| 18906869 | 0.030 | 1.52 | IFNG | interferon gamma |
| Sequential Therapy | ||||
| 18896172 | 0.043 | 2.01 | FAR2 | fatty acyl CoA reductase 2 |
| 18698492 | 0.010 | 1.46 | PADI2 | peptidyl arginine deiminase, type II |
| 19576522 | 0.008 | 1.43 | ZFP57 | zinc finger protein 57 homolog (mouse) |
| 18851261 | 0.000 | 1.35 | IL3RA | interleukin 3 receptor, alpha (low affinity) |
| 18892472 | 0.030 | 1.35 | CD3D | CD3D molecule, delta(CD3-TCR complex) |
| 18968132 | 0.029 | 1.35 | HRH4 | histamine receptor H4 |
| 18882589 | 0.007 | 1.34 | FOLR3 | folate receptor 3 (gamma) |
| 18728884 | 0.031 | −1.30 | PRKD3 | protein kinase D3 |
| 18872598 | 0.021 | −1.30 | TIMM23 | translocase of inner mitochondrial membrane 23 homolog (yeast) |
| 18891105 | 0.039 | −1.30 | RAB30 | |