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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Trends Genet. 2015 Feb 27;31(4):208–214. doi: 10.1016/j.tig.2015.02.001

Figure 2.

Figure 2

Simulations of tumor growth based on a simple model of proliferation. A. Stochasticity in the initial phase of tumor growth, illustrated by the number of tries it takes (Y axis) for a clone to grow to one million cells (as opposed to going extinct), as a function of the strength of the initial driver mutation (X axis). B. Results from a simulation exploring the effect of the balance between cell death and ‘terminal differentiation’ of nondividing cells. Only when drivers are weak (X axis) is there an appreciable difference in the number of generations it takes to reach one million cells.