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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Trends Biotechnol. 2015 Feb 20;33(4):230–236. doi: 10.1016/j.tibtech.2015.01.004

Box 1-Fig I.

Box 1-Fig I

Stromal ECM fiber remodeling stages. (A) Schematic diagram representing progressive remodeling within collagen fibers of ECM during tumorigenesis. (B) Micrographs acquired using multiphoton laser scanning microscopy illustrating TACS in Wnt-1 mouse breast cancer model. Reproduced and modified from open access available [13]. (C) Representative reconstituted confocal images obtained from in vitro fibroblast-derived ECM associated with murine squamous cell carcinoma. Reproduced and modified with permission from [17].