Table 2.

Primary problem substance and route of administration by sex and sexual orientation and adjusted odds ratios and 99.9% confidence intervals for multinomial regression analyses (separately by sex), adjusted for age, race, ethnicity, and initial treatment episode

	Male Participants			Female Participants
	Heterosexual n (%) reference group	Gay n (%) Adj. OR (99.9% CI)	Bisexual n (%) Adj. OR (99.9% CI)	Heterosexual n (%) reference group	Lesbian n (%) Adj. OR (99.9% CI)	Bisexual n (%) Adj. OR (99.9% CI)
Problem substance
Alcohol (reference group)	2145 (26.8%)	206 (26.2%)	50 (23.7%)	661 (21.2%)	45 (29.8%)	60 (23.0%)
Cocaine	2014 (25.2%)	93 (11.8%) 0.77 (0.50, 1.20)	46 (21.8%) 1.24 (0.62, 2.51)	707 (22.7%)	37 (24.5%) 0.93 (0.44, 1.97)	62 (23.8%) 1.04 (0.55, 1.98)
Heroin	2068 (25.8%)	73 (9.3%) 0.35 (0.22, 0.56)*	54 (25.6%) 0.92 (0.47, 1.79)	947 (30.4%)	34 (22.5%) 0.73 (0.35, 1.54)	63 (24.1%) 0.81 (0.43, 1.55)
Marijuana	859 (10.7%)	37 (4.7%) 0.93 (0.48, 1.81)	11 (5.2%) 0.95 (0.28, 3.18)	322 (10.3%)	9 (6.0%) 0.51 (0.15, 1.75)	27 (10.3%) 0.84 (0.35, 1.98)
Methamphetamine	619 (7.7%)	350 (44.5%) 6.43 (4.55, 9.09)*	46 (21.8%) 2.94 (1.46, 5.94)*	329 (10.5%)	17 (11.3%) 0.85 (0.34, 2.15)	38 (14.6%) 1.05 (0.50, 2.18)
Other	299 (3.7%)	28 (3.6%) 0.83 (0.41, 1.68)	4 (1.9%) 0.46 (0.08, 2.61)	154 (4.9%)	9 (6.0%) 1.042 (0.33, 3.28)	11 (4.2%) 0.74 (0.24, 2.28)
Route of administration
Oral (reference group)	2434 (30.7%)	232 (29.6%)	56 (26.8%)	802 (26.1%)	51 (34.0%)	69 (26.3%)
Smoked	2982 (37.6%)	284 (36.2%) 1.61 (1.16, 2.23)*	63 (30.1%) 1.16 (0.62, 2.20)	1178 (38.4%)	52 (34.7%) 0.73 (0.38, 1.41)	104 (39.7%) 0.98 (0.57, 1.70)
Injection (IV or intramuscular)	1991 (25.1%)	209 (26.7%) 1.01 (0.72, 1.43)	83 (39.7%) 1.47 (0.81, 2.66)	920 (30.0%)	38 (25.3%) 0.75 (0.37, 1.51)	72 (27.5%) 0.99 (0.54, 1.80)
Inhalation	520 (6.6%)	59 (7.5%) 1.67 (0.99, 2.82)	7 (3.3%) 0.69 (0.18, 2.63)	168 (5.5%)	9 (6.0%) 1.06 (0.36, 3.13)	17 (6.5%) 1.16 (0.45, 2.96)

^*Indicates an analysis where p <.001