Table 2.
Weighted fracture event rates by antidepressant class and time of follow-up
| Period | Drug | Number Contributing | Number of Events | Total Person Time (years) | Rate per 1,000 person-years |
|---|---|---|---|---|---|
| 0–30 Days | SNRI | 336,949.7 | 193.9 | 26,758.35 | 7.3 (4.4–12.0) |
| SSRI | 335,146.0 | 192.0 | 26,596.29 | 7.2 (6.3–8.3) | |
| 31–90 Days | SNRI | 313,478.2 | 284.7 | 47,917.74 | 5.9 (4.1–8.7) |
| SSRI | 310,930.0 | 297.0 | 47,471.80 | 6.3 (5.6–7.0) | |
| 91–360 Days | SNRI | 267,612.6 | 745.0 | 90,320.71 | 8.3 (6.5–10.5) |
| SSRI | 266,836.0 | 583.0 | 87,228.48 | 6.7 (6.2–7.3) | |
| 0–360 Days | SNRI | 336,949.7 | 1,223.6 | 164,996.80 | 7.5 (6.2–9.0) |
| SSRI | 335,146.0 | 1,072.0 | 161,296.57 | 6.7 (6.3–7.1) | |
| 361–720 Days | SNRI | 71,874.7 | 296.5 | 43,580.68 | 6.8 (4.7–10.0) |
| SSRI | 67,855.0 | 261.0 | 40,979.64 | 6.4 (5.7–7.2) | |
| 721–1080 Days | SNRI | 24,781.3 | 53.4 | 15,147.92 | 3.5 (1.9–6.4) |
| SSRI | 23,874.0 | 81.0 | 15,089.71 | 5.4 (4.3–6.7) | |
| 1081–1440 Days | SNRI | 8,857.7 | 11.9 | 6,010.73 | 2.0 (0.6–6.6) |
| SSRI | 9,292.0 | 35.0 | 6,437.72 | 5.5 (3.9–7.6) | |
| 1441–1800 Days | SNRI | 3,956.2 | 4.2 | 2,429.55 | 1.7 (0.2–12.4) |
| SSRI | 4,333.0 | 9.0 | 2,744.35 | 3.3 (1.7–6.3) | |
| >1800 Days | SNRI | 1,260.3 | 4.8 | 1,026.95 | 4.7 (0.6–34.3) |
| SSRI | 1,460.0 | 7.0 | 1,435.70 | 4.9 (2.3–10.4) | |
| 0–1800 Days | SNRI | 336,949.7 | 1,589.5 | 232,165.67 | 6.9 (5.9–8.2) |
| SSRI | 335,146.0 | 1,458.0 | 226,548.00 | 6.5 (6.2–6.8) |
SSRI = selective serotonin reuptake inhibitor; SNRI = serotonin norepinephrine reuptake inhibitor