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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: CNS Drugs. 2015 Mar;29(3):245–252. doi: 10.1007/s40263-015-0231-5

Table 3.

SNRI vs. SSRI Fracture Hazard Ratios

Analysis 1-Year HR (95% CI) 5-Year HR (95% CI)
7-Day GP 1.01 (0.78, 1.30) 1.03 (0.82, 1.30)
14-Day GP 0.98 (0.78, 1.25) 1.01 (0.82, 1.24)
30-Day GP 1.02 (0.83, 1.26) 1.02 (0.85, 1.23)
60-Day GP 1.11 (0.92, 1.36) 1.06 (0.90, 1.26)
90-Day GP 1.12 (0.93, 1.36) 1.06 (0.90, 1.26)
180-Day GP 1.09 (0.90, 1.31) 1.04 (0.88, 1.22)
360-Day GP 1.03 (0.86, 1.24) 1.01 (0.87, 1.18)
First treatment carried forward 1.02 (0.87, 1.21) 0.98 (0.87, 1.10)

SSRI = selective serotonin reuptake inhibitor; SNRI = serotonin norepinephrine reuptake inhibitor GP = grace period; HR = hazard ratio; CI = confidence interval