Table 4.

SNRI vs. SSRI Fracture Hazard Ratios, with vs. without depression diagnoses

	With Depression, Excluding Bipolar and Schizophrenic Disorders		Without Depression
Analysis	1-Year HR (95% CI)	5-Year HR (95% CI)	1-Year HR (95% CI)	5-Year HR (95% CI)
7-Day GP	1.34 (0.91, 1.96)	1.35 (0.95, 1.92)	0.83 (0.59, 1.17)	0.84 (0.62, 1.15)
14-Day GP	1.27 (0.88, 1.84)	1.26 (0.90, 1.76)	0.84 (0.62, 1.15)	0.87 (0.66, 1.13)
30-Day GP	1.22 (0.86, 1.72)	1.19 (0.88, 1.62)	0.92 (0.70, 1.21)	0.91 (0.72, 1.15)
60-Day GP	1.31 (0.95, 1.79)	1.22 (0.92, 1.60)	1.04 (0.80, 1.34)	0.98 (0.78, 1.22)
90-Day GP	1.30 (0.95, 1.77)	1.21 (0.92, 1.58)	1.05 (0.82, 1.34)	0.98 (0.79, 1.22)
180-Day GP	1.23 (0.91, 1.66)	1.15 (0.88, 1.50)	1.03 (0.81, 1.30)	0.97 (0.79, 1.19)
360-Day GP	1.17 (0.87, 1.57)	1.12 (0.87, 1.45)	0.98 (0.78, 1.23)	0.95 (0.78, 1.15)
First treatment carried forward	1.12 (0.86, 1.46)	1.06 (0.88, 1.29)	1.01 (0.82, 1.25)	0.94 (0.81, 1.09)

SSRI = selective serotonin reuptake inhibitor; SNRI = serotonin norepinephrine reuptake inhibitor GP = grace period; HR = hazard ratio; CI = confidence interval