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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Mar 4;1853(5):1219–1228. doi: 10.1016/j.bbamcr.2015.02.020

Figure 1. IL4Rα promotes the growth of mammary tumors at the primary site.

Figure 1

R221a or 4T1 sh-control (Ctl) or IL4Rα knockdown (KD) cells were orthotopically injected into the 4th mammary gland of mice. A) Representation of tumor latency for R221a (left, p < .0001) and 4T1 (right, p = NS) mammary tumors (R221a n = 16; 4T1 n = 14). B) Graphs of R221a (left) and 4T1 (right) mammary tumor volume over time calculated from tumor dimensions (R221a n = 16; 4T1 n = 14). C) Quantification of total Ki67 D) or cleaved caspase-3 positive area per 4T1 IL4Rα KD or sh-control mammary tumor area (n = 11). Murine tumor growth data represented in A&B was repeated with similar results obtained.