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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Chemosphere. 2015 Mar 3;128:299–306. doi: 10.1016/j.chemosphere.2015.02.027

Fig. 2. The toxicity of Linoleic acid (LA) is accurately predicted in a two-chemical mixture containing an HR96 inhibitor (triclosan or DHA).

Fig. 2

Acute toxicity tests were performed with low (A), medium (B) and high (C) concentrations of triclosan coupled with multiple concentrations of LA, or low (D), medium (E), and high (F) concentrations of DHA coupled with multiple concentrations of LA. Data are provided as mean ± 95% confidence intervals (n = 10). Statistical significance was determined by ANOVA followed by Tukey’s multiple comparison test (*p < 0.05, **p < 0.01) Letter ‘b’ represents a statistical difference in comparison to 2 μM LA, whereas the other statistically significant data is in comparison to the control group. The independent joint action model from CATAM was used to predict daphnid survival under mixture conditions with the average 95% confidence intervals from the toxicity tests used to predict variance in the model. The independent joint action model prediction is shown as a line in each of the graphs.