Skip to main content
. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Curr Opin Cell Biol. 2015 Feb 20;33:125–131. doi: 10.1016/j.ceb.2015.02.003

Figure 1. Schematic model proposing a general logic of acetyl-CoA utilization under fed versus fasted or growth versus survival states.

Figure 1

Under fed or growth states, acetyl-CoA is directed out of the mitochondria and to the cytosol and nucleus for use in lipid synthesis or histone acetylation. Nucleocytosolic amounts of acetyl-CoA increase relative to mitochondrial amounts. Under fasted or survival states, acetyl-CoA is channeled into the mitochondria for synthesis of ATP and ketone bodies. Mitochondrial amounts of acetyl-CoA increase relative to nucleocytosolic amounts. Fatty acid oxidation significantly increases mitochondrial acetyl-CoA.