Skip to main content
. Author manuscript; available in PMC: 2016 Apr 10.
Published in final edited form as: Biochem Biophys Res Commun. 2015 Feb 28;459(3):430–436. doi: 10.1016/j.bbrc.2015.02.122

Figure 1. Sunitinib increases insulin sensitivity in the mouse.

Figure 1

(A) Serum insulin levels in mice treated with sunitinib or vehicle for 21 days. (B) Glucose disposal rate and (C) Tissue-specific radiolabeled 2-deoxyglucose uptake in mice treated with sunitinib for 3 weeks before undergoing a hyperinsulinemic euglycemic clamp procedure (n=12 per group) (D) Expression level of key genes involved in glycolysis. (E) and (F) Lactate dehydrogenase and pyruvate kinase enzyme activity assays performed on cardiac lysates. Data are ± SEM with 8–12 mice per group. * P < 0.05, ** P < 0.01 and *** P < 0.001.