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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Cell Signal. 2015 Feb 26;27(6):1186–1197. doi: 10.1016/j.cellsig.2015.02.024

Figure 9.

Figure 9

Proteasome/ubiquitin protein degradative pathway controls AMPK function. Proteasome inhibition and accumulation of non-degraded Ub-protein conjugates is associated with alterations in mitochondrial bioenergetics and ROS formation followed by activation of AMPK. Protein ubiquitination can also affect glucose-dependent regulation of AMPK activity. Once activated AMPK can influence bioenergetic and degradative pathways, including autophagy, mitochondrial quality control mitophagy and promotes fatty acids oxidation.