Figure 3.
Negative shift in the nitroso-redox balance decreased phospholamban (PLB) phosphorylation via phosphatase activation. Summary data of PLB Serine16 phosphorylation (A) and phosphatase activity (B) in Sed and Ex-nNOSKO myocytes (±O2·− scavenger MENO) (n=4 hearts/group), * P<0.05 vs corresponding Sed. C) Summary data of phosphatase activity in Sed and Ex WT myocytes (±nNOS inhibitor SMLT) (n=4 hearts/group), # P<0.05 vs Sed-WT, * P<0.05 vs corresponding control. D) Summary data of PLB Serine16 phosphorylation in control (non-induced) and nNOSOE myocytes (n=6 hearts/group), * P<0.05.
