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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Mar 6;1853(5):1229–1239. doi: 10.1016/j.bbamcr.2015.02.023

Figure 5. Pharmacological inhibition of Pak1 with IPA 3 inhibits TGFβ1-induced EMT-associated morphological changes, cell scattering, and motility in prostate cancer cells.

Figure 5

A. Representative images of PC3 and DU145 cell scattering following 72 h treatments with TGFβ1 (5 ng/ml), or IPA 3 (15 μM), or a combination. B. Bar graph showing quantification of the cell scattering in DU145 cells as treated above (n= 4). C and D. Representative images and bar graph of PC3 cell migration following 48 h treatments of TGFβ1 (5 ng/ml), IPA 3 (15 μM), or a combination (n= 4). E and F. Representative images and bar graph of DU145 cell migration following 48 h treatments of TGFβ1 (5 ng/ml), IPA 3 (15 μM), or a combination (n= 4). *p<0.05 and **P<0.01, Data presented as Mean ± SEM.