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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Ann Biomed Eng. 2014 Oct 21;43(3):616–627. doi: 10.1007/s10439-014-1156-8

Figure 1. Biomaterial scaffold.

Figure 1

Schematic showing the steps towards an engineered construct where the scaffold is designed to harness the host tissue response and maximize the angiogenic response. The first step is to select the cell source and the biomaterial of interest. These two components are then assembled and trained in a bioreactor by applying tissue appropriate biophysical forces. At this stage, a vasculature can be formed and perfused in vitro. This “artificial vasculature” can then be connected to the host tissue vasculature by harnessing the inflammatory response at the site of implantation. Artwork provided by Servier Medical Arts.