Table 2.

Examples of previous computational tissue engineering work that could be leveraged when creating Tier 3 of the model.

Author	Year	Hallmark of Model
Humphrey28	2003	Theoretically constrained mixture growth model to predict development of residual stresses and changes in material properties by considering that each component of the artery can evolve separately with its own turnover rate.
Driessen8	2008	Simulates the structure remodeling in cardiovascular tissues associated with the angular collagen fiber distribution within the arterial wall and aortic valve.
Raykin50	2009	Framework for gel-based tissue-engineered blood vessels that predicts tissue geometry and material properties for gels under both static and dynamic loading conditions.
Kroon31	2010	Incorporation of remodeling and reorientation of collagen fibers by assuming collagen fibers reorient toward the direction of maximum Cauchy stress; model successfully predicts both collagen alignment and stress-strain curves of the tissues.
Kroon31	2010	Computational model for myocardial tissue that assumes fibers reorient to minimize shear; model successfully predicts myofibril reorientation of native tissue under hemodynamic loads.